A dance is coming up, setting the young girls in a tizzy. Colleen decides to no longer be friends with the most popular girl in town (Alice) because she is bossy. Dorothy is feeling puny, and when Dr. Mike questions her, it's revealed she is pregnant just as Loren walks into her room; the three fall into an uncomfortable silence. Further examination shows it's not a pregnancy but menopause, which upsets Dorothy deeply. Colleen commissions Robert E. to make a Best Friends necklace. Dorothy begins bleeding heavily, which may require taking out her uterus. Colleen's friend Becky asks her to speak to a boy, but the young man inadvertently thinks Colleen is sweet on him. Loren gives Dorothy a meal in bed, wracked with guilt about believing Hank's false stories on menopause. Colleen goes to meet her friend's crush under the tree and receives her first kiss. Sully stalks off after Dr. Mike tries to teach him to dance. Michaela admits to Dorothy she is afraid of physical intimacy, but after church she notices Sully going into the store alone with Dorothy and becomes suspicious. Becky catches Colleen kissing the boy she likes and they argue. Dr. Mike finally hears about Colleen's problem and points out friendship should be above boyfriends. While in Loren's store, Sully and Dorothy come out of her room laughing. Michaela is ready to explode in anger but Dorothy collapses and is bleeding badly. Loren predicts doom and gloom but when Dorothy comes out fine, he faints dead away in front of the clinic. Colleen becomes the butt of vicious rumours at school and dumps the boyfriend. Loren asks Dorothy to the dance—but just to sit; either way she won't tell Dr. Mike what Sully was doing with her, and neither will he. At the dance, Loren admits he still has feelings for Dorothy, Alice steals the boy and Becky decides he's not worth it, and Sully dances a perfect Sweetheart Reel—thanks, of course, to the lessons from Dorothy.
